Effect of somatostatin (growth hormone inhibiting factor: GIF) on TRH-induced TSH release in rats.
نویسندگان
چکیده
Intravenous preadministration of somatostatin (Growth Hormone Inhibiting Factor: GIF) inhibited TRH-induced TSH release in rats anesthesized by pentobarbitulate. There was dose dependent negative interaction between the inhibitory effect of GIF and releasing effect of TRH. TSH releasing effect of small dose of TRH was inhibited completely by preadministration of GIF, while large dose of TRH overcame the inhibitory effect of GIF. The mechanism responsible for inhibitory effect of GIF on TRH-induced TSH release was discussed.
منابع مشابه
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ورودعنوان ژورنال:
- Endocrinologia japonica
دوره 21 5 شماره
صفحات -
تاریخ انتشار 1974